Medicinal plants have been have been used for centuries to treat various diseases across the world. While plant extracts have been used to synthesize modern commercial drugs, so far only a small percent of traditionally prescribed plant medicines have been studied for their therapeutic value. In recent years, the American public has become enamored with herbal remedies, yet there continues to be a relative scarcity of scientific research. Echinacea (purple coneflower) has received global attention because of its potential for medicinal value. Extensive laboratory and clinical research on Echinacea angustifolia in the last few years in Germany has confirmed its immunostimulatory, antiviral, and antibacterial benefit to humans. The purpose of this study is to use the agar-well diffusion method to compare antimicrobial activity of cultivated and wild E. angustifolia. We hypothesize that cultivated E. angustifolia will show more antimicrobial activity against five different strains of bacteria (two Gram-negative, three Gram-positive) due to being cultivated under ideal conditions.